Assay Detail
Functional
CHEMBL4008248
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Antiviral activity against GFP-fused Ebolavirus infected in TERT-immortalized HMVEC assessed as reduction in viral replication preincubated with cells followed by viral infection measured after 3 to 4 days by fluorescence assay
24
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ebolavirus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.03 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061258 | — | — | 1 | 7.28 |
| CHEMBL4065616 | REMDESIVIR | 4.0 | 2 | 7.28 |
| CHEMBL4065821 | — | — | 1 | 7.06 |
| CHEMBL4083126 | — | — | 1 | 7.04 |
| CHEMBL4072649 | — | — | 1 | 6.80 |
| CHEMBL4064050 | — | — | 1 | 6.43 |
| CHEMBL4090912 | — | — | 1 | 6.29 |
| CHEMBL4084735 | — | — | 1 | 6.23 |
| CHEMBL4093434 | — | — | 1 | 6.20 |
| CHEMBL4098638 | — | — | 1 | 6.17 |
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 6.11 |
| CHEMBL4099554 | — | — | 1 | 6.07 |
| CHEMBL4074442 | — | — | 1 | 5.80 |
| CHEMBL4101182 | — | — | 1 | 5.50 |
| CHEMBL4091811 | — | — | 1 | 5.42 |
| CHEMBL4086934 | — | — | 1 | 5.41 |
| CHEMBL4069927 | — | — | 1 | 5.04 |
| CHEMBL3120789 | — | — | 1 | 4.89 |
| CHEMBL3120793 | GS-6620 | 1.0 | 1 | 4.40 |
| CHEMBL4065501 | — | — | 1 | 4.25 |
| CHEMBL3120779 | — | — | 1 | - |
| CHEMBL4090316 | — | — | 1 | - |
| CHEMBL2016758 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061258 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4065821 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4083126 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4072649 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4064050 | — | EC50 | = | 367.0 | nM | 6.43 |
| CHEMBL4090912 | — | EC50 | = | 518.0 | nM | 6.29 |
| CHEMBL4084735 | — | EC50 | = | 587.0 | nM | 6.23 |
| CHEMBL4093434 | — | EC50 | = | 636.0 | nM | 6.20 |
| CHEMBL4098638 | — | EC50 | = | 678.0 | nM | 6.17 |
| CHEMBL2016757 | GS-441524 | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4099554 | — | EC50 | = | 845.0 | nM | 6.07 |
| CHEMBL4074442 | — | EC50 | = | 1585.0 | nM | 5.80 |
| CHEMBL4101182 | — | EC50 | = | 3151.0 | nM | 5.50 |
| CHEMBL4091811 | — | EC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL4086934 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4069927 | — | EC50 | = | 9102.0 | nM | 5.04 |
| CHEMBL3120789 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3120793 | GS-6620 | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4065501 | — | EC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL3120779 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4090316 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2016758 | — | EC50 | > | 10000.0 | nM | - |