Assay Detail
Binding
CHEMBL4008772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDM1B (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 2 (CHEMBL1938208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.36 | 4.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3906257 | — | — | 1 | 4.36 |
| CHEMBL4090002 | — | — | 1 | - |
| CHEMBL4083038 | — | — | 1 | - |
| CHEMBL4086085 | — | — | 1 | - |
| CHEMBL4066708 | — | — | 1 | - |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3906257 | — | IC50 | = | 43400.0 | nM | 4.36 |
| CHEMBL4090002 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4083038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4086085 | — | IC50 | - | — | - | |
| CHEMBL4066708 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | > | 100000.0 | nM | - |