Assay Detail
Binding
CHEMBL4008884
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Inhibition of hyaluronidase (unknown origin) using hyaluronic acid as substrate preincubated for 20 mins followed by substrate addition measured after 40 mins by colorimetric method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.72 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441687 | GLYCYRRHIZIN | 2.0 | 1 | 5.07 |
| CHEMBL1773982 | — | — | 1 | 4.62 |
| CHEMBL488317 | GINSENOSIDE R0 | — | 1 | 4.47 |
| CHEMBL200715 | (-)-CATECHIN | — | 1 | - |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | - |
| CHEMBL485818 | BAICALIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441687 | GLYCYRRHIZIN | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1773982 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL488317 | GINSENOSIDE R0 | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL200715 | (-)-CATECHIN | IC50 | = | 1100000.0 | nM | - |
| CHEMBL583912 | (-)-EPICATECHIN | IC50 | = | 804000.0 | nM | - |
| CHEMBL485818 | BAICALIN | IC50 | = | 506000.0 | nM | - |