Compound Detail
CHEMBL488317
GINSENOSIDE R0 Enter ChEMBL ID:
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CC1(C)CC[C@]2(C(=O)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]6O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1
Basic Information
| ChEMBL ID | CHEMBL488317 |
| Name | GINSENOSIDE R0 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NFZYDZXHKFHPGA-QQHDHSITSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
957.1
MW (Da)
0.23
ALogP
18
HBA
11
HBD
312.1
PSA (Ų)
0.08
QED
3
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 4.47 | 4.47 | 34000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 34000.0 | nM | 4.47 | Inhibition of hyaluronidase (unknown origin) using hyaluronic acid as substrate ... | 28202328 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2849641 | 10.1021/np50059a019 | Unchecked | 1 |
| 28202328 | 10.1016/j.bmcl.2017.01.083 | Unchecked | 1 |
| 28478866 | 10.1016/j.bmc.2017.04.023 | Amyloid-beta precursor protein | 1 |
| 33131725 | 10.1016/j.ejmech.2020.112932 | AMP-activated protein kinase, AMPK | 1 |
| 29353722 | 10.1016/j.ejmech.2018.01.011 | Hepatocyte | 1 |
Data from ChEMBL 36 via Core Engine