Assay Detail
Binding
CHEMBL4009503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR delE746_A750 mutant in human HCC827 cells assessed as reduction in cell viability after 96 hrs by CellTiterGlo assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.29 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068763 | — | — | 1 | 7.66 |
| CHEMBL3545308 | ROCILETINIB | 3.0 | 1 | 7.35 |
| CHEMBL4071463 | — | — | 1 | 7.01 |
| CHEMBL4079501 | — | — | 1 | 6.97 |
| CHEMBL4060039 | — | — | 1 | 6.92 |
| CHEMBL4088277 | — | — | 1 | 6.79 |
| CHEMBL4098444 | — | — | 1 | 6.40 |
| CHEMBL4097594 | — | — | 1 | 6.34 |
| CHEMBL4080424 | — | — | 1 | 6.14 |
| CHEMBL4103757 | — | — | 1 | 6.13 |
| CHEMBL4060103 | — | — | 1 | 6.12 |
| CHEMBL4082000 | — | — | 1 | 6.07 |
| CHEMBL4089863 | — | — | 1 | 5.96 |
| CHEMBL4079566 | — | — | 1 | 5.73 |
| CHEMBL4061043 | — | — | 1 | 5.63 |
| CHEMBL4098500 | — | — | 1 | 5.60 |
| CHEMBL4074766 | — | — | 1 | 5.33 |
| CHEMBL4090330 | — | — | 1 | 5.01 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | - |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | - |
| CHEMBL4065517 | — | — | 1 | - |
| CHEMBL4069284 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068763 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3545308 | ROCILETINIB | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4071463 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4079501 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4060039 | — | EC50 | = | 121.0 | nM | 6.92 |
| CHEMBL4088277 | — | EC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4098444 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4097594 | — | EC50 | = | 459.0 | nM | 6.34 |
| CHEMBL4080424 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4103757 | — | EC50 | = | 734.0 | nM | 6.13 |
| CHEMBL4060103 | — | EC50 | = | 765.0 | nM | 6.12 |
| CHEMBL4082000 | — | EC50 | = | 856.0 | nM | 6.07 |
| CHEMBL4089863 | — | EC50 | = | 1095.0 | nM | 5.96 |
| CHEMBL4079566 | — | EC50 | = | 1846.0 | nM | 5.73 |
| CHEMBL4061043 | — | EC50 | = | 2348.0 | nM | 5.63 |
| CHEMBL4098500 | — | EC50 | = | 2522.0 | nM | 5.60 |
| CHEMBL4074766 | — | EC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL4090330 | — | EC50 | = | 9813.0 | nM | 5.01 |
| CHEMBL3353410 | OSIMERTINIB | EC50 | < | 14.0 | nM | - |
| CHEMBL939 | GEFITINIB | EC50 | < | 14.0 | nM | - |
| CHEMBL4065517 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4069284 | — | EC50 | > | 30000.0 | nM | - |