Assay Detail
Binding
CHEMBL4009723
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Inhibition of SPHK2 (unknown origin) by FITC-based caliper assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.91 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4104017 | — | — | 1 | 8.62 |
| CHEMBL4063506 | — | — | 1 | 6.84 |
| CHEMBL4069327 | — | — | 1 | 6.79 |
| CHEMBL4090361 | — | — | 1 | 6.79 |
| CHEMBL3134157 | — | — | 1 | 6.45 |
| CHEMBL4077280 | — | — | 1 | 6.35 |
| CHEMBL4061789 | — | — | 1 | 6.33 |
| CHEMBL4063424 | — | — | 1 | 5.14 |
| CHEMBL4103414 | — | — | 1 | 4.46 |
| CHEMBL4101573 | — | — | 1 | 4.40 |
| CHEMBL3348835 | — | — | 1 | 4.37 |
| CHEMBL4082814 | — | — | 1 | 4.34 |
| CHEMBL4077075 | — | — | 1 | - |
| CHEMBL4064624 | — | — | 1 | - |
| CHEMBL4093845 | — | — | 1 | - |
| CHEMBL4066270 | — | — | 1 | - |
| CHEMBL4086094 | — | — | 1 | - |
| CHEMBL4088607 | — | — | 1 | - |
| CHEMBL4067356 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4104017 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4063506 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4069327 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL4090361 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL3134157 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL4077280 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL4061789 | — | IC50 | = | 465.0 | nM | 6.33 |
| CHEMBL4063424 | — | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL4103414 | — | IC50 | = | 35100.0 | nM | 4.46 |
| CHEMBL4101573 | — | IC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL3348835 | — | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL4082814 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4077075 | — | IC50 | - | — | - | |
| CHEMBL4064624 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4093845 | — | IC50 | - | — | - | |
| CHEMBL4066270 | — | IC50 | < | 1.7 | nM | - |
| CHEMBL4086094 | — | IC50 | < | 1.7 | nM | - |
| CHEMBL4088607 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4067356 | — | IC50 | > | 100000.0 | nM | - |