Assay Detail
Functional
CHEMBL4009782
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Antiproliferative activity against human A375 cells after 72 hrs by SRB assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine derivatives as mTOR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.41 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.92 |
| CHEMBL4061268 | — | — | 1 | 5.80 |
| CHEMBL4095235 | — | — | 1 | 5.75 |
| CHEMBL4089423 | — | — | 1 | 5.70 |
| CHEMBL4083096 | — | — | 1 | 5.64 |
| CHEMBL4093332 | — | — | 1 | 5.48 |
| CHEMBL4088635 | — | — | 1 | 5.47 |
| CHEMBL4077736 | — | — | 1 | 5.39 |
| CHEMBL4097280 | — | — | 1 | 5.39 |
| CHEMBL4102004 | — | — | 1 | 5.38 |
| CHEMBL4070976 | — | — | 1 | 5.33 |
| CHEMBL4091820 | — | — | 1 | 5.24 |
| CHEMBL4074775 | — | — | 1 | 5.19 |
| CHEMBL4084062 | — | — | 1 | 5.14 |
| CHEMBL4081558 | — | — | 1 | 5.11 |
| CHEMBL4074759 | — | — | 1 | 5.10 |
| CHEMBL4099562 | — | — | 1 | 4.96 |
| CHEMBL4062346 | — | — | 1 | 4.95 |
| CHEMBL4085248 | — | — | 1 | 4.80 |
| CHEMBL4072621 | — | — | 1 | - |
| CHEMBL4101069 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4061268 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4095235 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4089423 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4083096 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4093332 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4088635 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4077736 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4097280 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4102004 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4070976 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4091820 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4074775 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4084062 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4081558 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4074759 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4099562 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4062346 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4085248 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL4072621 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4101069 | — | IC50 | > | 40000.0 | nM | - |