Assay Detail
Binding
CHEMBL4009967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at DAT in rat synaptosomes assessed as release of [3H]DA after 5 mins by liquid scintillation counting method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.59 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4084187 | — | — | 1 | 7.83 |
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 7.60 |
| CHEMBL3330645 | — | — | 1 | 7.19 |
| CHEMBL1788307 | — | — | 1 | 7.01 |
| CHEMBL195390 | — | — | 1 | 6.85 |
| CHEMBL6731 | TENAMFETAMINE | 2.0 | 1 | 6.72 |
| CHEMBL43048 | MIDOMAFETAMINE | 3.0 | 1 | 6.56 |
| CHEMBL1927025 | — | — | 1 | 6.05 |
| CHEMBL3330646 | — | — | 1 | 6.05 |
| CHEMBL4104749 | — | — | 1 | 6.00 |
| CHEMBL4086874 | — | — | 1 | 5.80 |
| CHEMBL382757 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4084187 | — | EC50 | = | 14.8 | nM | 7.83 |
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3330645 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1788307 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL195390 | — | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL6731 | TENAMFETAMINE | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL43048 | MIDOMAFETAMINE | EC50 | = | 278.0 | nM | 6.56 |
| CHEMBL1927025 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3330646 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4104749 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4086874 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL382757 | — | EC50 | = | 3700.0 | nM | 5.43 |