Assay Detail
Binding
CHEMBL4009977
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Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampal membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.52 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.92 |
| CHEMBL11760 | — | — | 1 | 8.89 |
| CHEMBL285351 | — | — | 1 | 8.72 |
| CHEMBL27937 | — | — | 1 | 8.70 |
| CHEMBL28111 | — | — | 1 | 8.68 |
| CHEMBL27019 | — | — | 1 | 8.64 |
| CHEMBL27609 | — | — | 1 | 8.60 |
| CHEMBL27252 | — | — | 1 | 8.25 |
| CHEMBL26688 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL11760 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL285351 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL27937 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL28111 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL27019 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL27609 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL27252 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL26688 | — | Ki | = | 53.0 | nM | 7.28 |