Assay Detail
Binding
CHEMBL4009980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (+)-[3H]pentazocine from guinea pig brain membrane sigma1 receptor by scintillation spectrometric method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 9.37 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304079 | — | — | 1 | 10.15 |
| CHEMBL4073530 | — | — | 1 | 10.10 |
| CHEMBL4072342 | — | — | 1 | 9.85 |
| CHEMBL19544 | — | — | 1 | 9.60 |
| CHEMBL20348 | — | — | 1 | 9.54 |
| CHEMBL20188 | — | — | 1 | 9.42 |
| CHEMBL280160 | — | — | 1 | 9.30 |
| CHEMBL20700 | — | — | 1 | 9.05 |
| CHEMBL4093106 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304079 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL4073530 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL4072342 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL19544 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL20348 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL20188 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL280160 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL20700 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4093106 | — | Ki | = | 48.0 | nM | 7.32 |