Assay Detail
Binding
CHEMBL4009989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat cortex membranes after 15 mins by liquid scintillation spectrometric method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.60 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26998 | — | — | 1 | 8.31 |
| CHEMBL164814 | — | — | 1 | 8.02 |
| CHEMBL168114 | — | — | 1 | 7.12 |
| CHEMBL351641 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26998 | — | Ki | = | 4.84 | nM | 8.31 |
| CHEMBL164814 | — | Ki | = | 9.65 | nM | 8.02 |
| CHEMBL168114 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL351641 | — | Ki | = | 109.0 | nM | 6.96 |