Assay Detail
Binding
CHEMBL4010154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis
30
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 6.07 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060403 | — | — | 1 | 6.68 |
| CHEMBL4063235 | — | — | 1 | 6.68 |
| CHEMBL4091155 | — | — | 1 | 6.62 |
| CHEMBL4091064 | — | — | 1 | 6.60 |
| CHEMBL4079301 | — | — | 1 | 6.55 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 6.51 |
| CHEMBL4072821 | — | — | 1 | 6.39 |
| CHEMBL4098236 | — | — | 1 | 6.37 |
| CHEMBL4105030 | — | — | 1 | 6.36 |
| CHEMBL4087187 | — | — | 1 | 6.33 |
| CHEMBL4071868 | — | — | 1 | 6.22 |
| CHEMBL4060461 | — | — | 2 | 6.15 |
| CHEMBL4078348 | — | — | 1 | 6.10 |
| CHEMBL4070091 | — | — | 1 | 6.07 |
| CHEMBL4096353 | — | — | 1 | 6.05 |
| CHEMBL4099711 | — | — | 1 | 6.04 |
| CHEMBL4069145 | — | — | 1 | 6.00 |
| CHEMBL4098803 | — | — | 1 | 5.96 |
| CHEMBL4088639 | — | — | 1 | 5.92 |
| CHEMBL4090208 | — | — | 1 | 5.89 |
| CHEMBL4071185 | — | — | 1 | 5.85 |
| CHEMBL4067439 | — | — | 1 | 5.85 |
| CHEMBL4063282 | — | — | 1 | 5.77 |
| CHEMBL4098859 | — | — | 1 | 5.75 |
| CHEMBL4097330 | — | — | 1 | 5.68 |
| CHEMBL4080762 | — | — | 1 | 5.55 |
| CHEMBL4069091 | — | — | 1 | 5.54 |
| CHEMBL4094869 | — | — | 1 | 5.43 |
| CHEMBL4102616 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060403 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL4063235 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL4091155 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL4091064 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4079301 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL4072821 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL4098236 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL4105030 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL4087187 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL4071868 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL4060461 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL4078348 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL4060461 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL4070091 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL4096353 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL4099711 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL4069145 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4098803 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL4088639 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL4090208 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL4071185 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL4067439 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL4063282 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL4098859 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL4097330 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL4080762 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL4069091 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL4094869 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL4102616 | — | Ki | = | 8600.0 | nM | 5.07 |