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Assay Detail

CHEMBL4010243

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human carbonic anhydrase 7 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 7 (CHEMBL2326)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment.
Mishra CB, Kumari S, Angeli A, Monti SM, Buonanno M, Tiwari M, Supuran CT.
J Med Chem (2017) 60 : 2456 -2469
PubMed 28253618 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 26 7.48 9.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4097153 1 9.13
CHEMBL220492 TOPIRAMATE 4.0 1 9.05
CHEMBL20 ACETAZOLAMIDE 4.0 1 8.60
CHEMBL4070147 1 8.59
CHEMBL4083316 1 8.40
CHEMBL1518113 1 8.19
CHEMBL4091108 1 8.05
CHEMBL4086993 1 8.03
CHEMBL4080804 1 7.98
CHEMBL1363627 1 7.68
CHEMBL4094554 1 7.23
CHEMBL4061487 1 7.19
CHEMBL4104861 1 6.79
CHEMBL4067239 1 6.73
CHEMBL4089446 1 6.69
CHEMBL4081575 1 6.52
CHEMBL4099828 1 6.51
CHEMBL4102291 1 6.50
CHEMBL4098919 1 6.44
CHEMBL4094688 1 6.39
CHEMBL4068266 1 6.31
CHEMBL4059623 1 -
CHEMBL4080884 1 -
CHEMBL4084329 1 -
CHEMBL4074004 1 -
CHEMBL4072947 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4097153 Ki = 0.74 nM 9.13
CHEMBL220492 TOPIRAMATE Ki = 0.9 nM 9.05
CHEMBL20 ACETAZOLAMIDE Ki = 2.5 nM 8.60
CHEMBL4070147 Ki = 2.6 nM 8.59
CHEMBL4083316 Ki = 4.0 nM 8.40
CHEMBL1518113 Ki = 6.5 nM 8.19
CHEMBL4091108 Ki = 8.9 nM 8.05
CHEMBL4086993 Ki = 9.4 nM 8.03
CHEMBL4080804 Ki = 10.5 nM 7.98
CHEMBL1363627 Ki = 21.0 nM 7.68
CHEMBL4094554 Ki = 58.5 nM 7.23
CHEMBL4061487 Ki = 64.5 nM 7.19
CHEMBL4104861 Ki = 161.0 nM 6.79
CHEMBL4067239 Ki = 188.0 nM 6.73
CHEMBL4089446 Ki = 203.0 nM 6.69
CHEMBL4081575 Ki = 299.0 nM 6.52
CHEMBL4099828 Ki = 310.0 nM 6.51
CHEMBL4102291 Ki = 318.0 nM 6.50
CHEMBL4098919 Ki = 360.0 nM 6.44
CHEMBL4094688 Ki = 404.0 nM 6.39
CHEMBL4068266 Ki = 490.0 nM 6.31
CHEMBL4059623 Ki > 50000.0 nM -
CHEMBL4080884 Ki > 50000.0 nM -
CHEMBL4084329 Ki > 50000.0 nM -
CHEMBL4074004 Ki > 50000.0 nM -
CHEMBL4072947 Ki > 50000.0 nM -