Assay Detail
Binding
CHEMBL4010335
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Inhibition of human DcpS assessed as increase in SMN2 promoter activity
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 9.19 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL251906 | — | — | 1 | 10.70 |
| CHEMBL251428 | — | — | 1 | 10.70 |
| CHEMBL251429 | — | — | 1 | 10.52 |
| CHEMBL4080254 | — | — | 1 | 10.52 |
| CHEMBL4082618 | — | — | 1 | 10.40 |
| CHEMBL255019 | — | — | 1 | 10.30 |
| CHEMBL4072132 | — | — | 1 | 10.16 |
| CHEMBL1232147 | — | — | 1 | 10.10 |
| CHEMBL4077061 | — | — | 1 | 9.96 |
| CHEMBL250072 | — | — | 1 | 9.96 |
| CHEMBL398675 | — | — | 1 | 9.72 |
| CHEMBL4062544 | — | — | 1 | 9.60 |
| CHEMBL4061457 | — | — | 1 | 9.57 |
| CHEMBL399673 | — | — | 1 | 9.54 |
| CHEMBL4076514 | — | — | 1 | 9.49 |
| CHEMBL342595 | — | — | 1 | 9.00 |
| CHEMBL4103454 | — | — | 1 | 8.86 |
| CHEMBL4068466 | — | — | 1 | 8.75 |
| CHEMBL4072481 | — | — | 1 | 8.64 |
| CHEMBL250231 | — | — | 1 | 8.54 |
| CHEMBL343543 | — | — | 1 | 8.10 |
| CHEMBL4075292 | — | — | 1 | 7.98 |
| CHEMBL4100442 | — | — | 1 | 7.91 |
| CHEMBL4084161 | — | — | 1 | 7.87 |
| CHEMBL4090641 | — | — | 1 | 7.79 |
| CHEMBL268354 | — | — | 1 | 6.85 |
| CHEMBL4093512 | — | — | 1 | 6.48 |
| CHEMBL4102384 | — | — | 1 | - |
| CHEMBL4075512 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL251906 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL251428 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL251429 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4080254 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4082618 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL255019 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL4072132 | — | IC50 | = | 0.069 | nM | 10.16 |
| CHEMBL1232147 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL4077061 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL250072 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL398675 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4062544 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4061457 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL399673 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL4076514 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL342595 | — | IC50 | = | 1.01 | nM | 9.00 |
| CHEMBL4103454 | — | IC50 | = | 1.39 | nM | 8.86 |
| CHEMBL4068466 | — | IC50 | = | 1.77 | nM | 8.75 |
| CHEMBL4072481 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL250231 | — | IC50 | = | 2.89 | nM | 8.54 |
| CHEMBL343543 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4075292 | — | IC50 | = | 10.55 | nM | 7.98 |
| CHEMBL4100442 | — | IC50 | = | 12.31 | nM | 7.91 |
| CHEMBL4084161 | — | IC50 | = | 13.59 | nM | 7.87 |
| CHEMBL4090641 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL268354 | — | IC50 | = | 142.58 | nM | 6.85 |
| CHEMBL4093512 | — | IC50 | = | 334.3 | nM | 6.48 |
| CHEMBL4102384 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4075512 | — | IC50 | > | 10000.0 | nM | - |