Assay Detail
Functional
CHEMBL4010348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Sensitization of TRAIL-induced apoptosis in human ACHN cells assessed as reduction in cell viability preincubated for 2 hrs followed by addition of TRAIL measured after 18 hrs by MTS assay
37
Total Activities
37
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ACHN |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.49 | 7.17 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4067062 | — | — | 1 | 7.17 |
| CHEMBL4085888 | — | — | 1 | 7.12 |
| CHEMBL4068082 | — | — | 1 | 7.05 |
| CHEMBL4086806 | — | — | 1 | 6.96 |
| CHEMBL3605565 | — | — | 1 | 6.79 |
| CHEMBL4072142 | — | — | 1 | 6.79 |
| CHEMBL4089270 | — | — | 1 | 6.78 |
| CHEMBL4104704 | — | — | 1 | 6.63 |
| CHEMBL4092901 | — | — | 1 | 6.60 |
| CHEMBL4100635 | — | — | 1 | 6.55 |
| CHEMBL1097107 | WITHANOLIDE E | — | 1 | 6.31 |
| CHEMBL3605564 | — | — | 1 | 6.25 |
| CHEMBL502563 | — | — | 1 | 6.25 |
| CHEMBL4075419 | — | — | 1 | 5.90 |
| CHEMBL4093863 | — | — | 1 | 5.78 |
| CHEMBL4064347 | — | — | 1 | 5.75 |
| CHEMBL4077218 | — | — | 1 | 5.71 |
| CHEMBL4083229 | — | — | 1 | - |
| CHEMBL4091018 | — | — | 1 | - |
| CHEMBL3605561 | — | — | 1 | - |
| CHEMBL3605566 | — | — | 1 | - |
| CHEMBL4088580 | — | — | 1 | - |
| CHEMBL4060349 | — | — | 1 | - |
| CHEMBL4101943 | — | — | 1 | - |
| CHEMBL4066909 | — | — | 1 | - |
| CHEMBL4060133 | — | — | 1 | - |
| CHEMBL3234488 | — | — | 1 | - |
| CHEMBL3605562 | — | — | 1 | - |
| CHEMBL4075872 | — | — | 1 | - |
| CHEMBL4066283 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4067062 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4085888 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4068082 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4086806 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL3605565 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL4072142 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL4089270 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL4104704 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4092901 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL4100635 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL1097107 | WITHANOLIDE E | IC50 | = | 489.0 | nM | 6.31 |
| CHEMBL3605564 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL502563 | — | IC50 | = | 563.0 | nM | 6.25 |
| CHEMBL4075419 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4093863 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL4064347 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4077218 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL517080 | WITHAFERIN A | IC50 | > | 2000.0 | nM | - |
| CHEMBL4094530 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4082632 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4085159 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4074906 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4101595 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4066298 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4066283 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4075872 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL3605562 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL3234488 | — | Activity | - | — | - | |
| CHEMBL4060133 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4066909 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4101943 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4060349 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4088580 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL3605566 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL3605561 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4091018 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL4083229 | — | IC50 | > | 4000.0 | nM | - |