Assay Detail
Binding
CHEMBL4011336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from mouse A3AR expressed in HEK293T cells pre-incubated for 10 mins before radioligand addition and measured 90 mins after radioligand addition by micro beta scintillation counting analysis relative to control
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.18 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4092411 | — | — | 1 | 7.47 |
| CHEMBL4086593 | — | — | 1 | 6.22 |
| CHEMBL4090355 | — | — | 1 | 5.93 |
| CHEMBL4097426 | — | — | 1 | 5.75 |
| CHEMBL4105127 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4092411 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL4086593 | — | Ki | = | 597.0 | nM | 6.22 |
| CHEMBL4090355 | — | Ki | = | 1170.0 | nM | 5.93 |
| CHEMBL4097426 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL4105127 | — | Ki | = | 2810.0 | nM | 5.55 |