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Assay Detail

CHEMBL4011338

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from human A3AR expressed in CHO cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Transmembrane domain-containing protein TMIGD3 (CHEMBL3712907)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.
Tosh DK, Janowsky A, Eshleman AJ, Warnick E, Gao ZG, Chen Z, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA.
J Med Chem (2017) 60 : 3109 -3123
PubMed 28319392 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.77 8.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3612940 1 8.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3612940 Ki = 1.69 nM 8.77