Assay Detail
Binding
CHEMBL4011349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Enhancing of [125I]RTI-55 binding to mouse DAT expressed in HEK293 cells preincubated for 10 mins followed by radioligand addition measured after 90 mins by micro beta scintillation counting analysis
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL2799) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.85 | 6.09 |
| Emax | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4066973 | — | — | 2 | 6.09 |
| CHEMBL4093756 | — | — | 2 | 5.97 |
| CHEMBL3407785 | — | — | 2 | 5.96 |
| CHEMBL3407784 | — | — | 2 | 5.65 |
| CHEMBL4071867 | — | — | 2 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4066973 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4093756 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL3407785 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3407784 | — | EC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL4071867 | — | EC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL3407784 | — | Emax | = | 1150.0 | % | - |
| CHEMBL3407785 | — | Emax | = | 810.0 | % | - |
| CHEMBL4071867 | — | Emax | = | 1000.0 | % | - |
| CHEMBL4066973 | — | Emax | = | 1440.0 | % | - |
| CHEMBL4093756 | — | Emax | = | 1560.0 | % | - |