Assay Detail
ADMET
CHEMBL4011672
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell plasma membrane vesicles assessed as reduction in ATP-dependent [3H]-taurocholate uptake in to vesicles preincubated for 10 mins followed by ATP addition measured after 10 to 15 mins by TopCount method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Subcellular | Plasma Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.97 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.40 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 5.66 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.47 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 5.43 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 5.23 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 5.19 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.10 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 5.10 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.96 |
| CHEMBL2218877 | ERYTHROMYCIN ESTOLATE | 4.0 | 1 | 4.89 |
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 4.89 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.82 |
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | 4.79 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 4.67 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 4.61 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.60 |
| CHEMBL444633 | RIFABUTIN | 4.0 | 1 | 4.57 |
| CHEMBL1231 | OXYBUTYNIN | 4.0 | 1 | 4.56 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 4.55 |
| CHEMBL2220442 | FLUVASTATIN | 4.0 | 1 | 4.44 |
| CHEMBL655 | MIDAZOLAM | 4.0 | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL163 | RITONAVIR | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL121 | ROSIGLITAZONE | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL554 | LAPATINIB | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1484 | NICARDIPINE | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL939 | GEFITINIB | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL2218877 | ERYTHROMYCIN ESTOLATE | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1017 | TELMISARTAN | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL5483011 | INDINAVIR | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL941 | IMATINIB | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL444633 | RIFABUTIN | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL1231 | OXYBUTYNIN | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL710 | FINASTERIDE | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL2220442 | FLUVASTATIN | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL655 | MIDAZOLAM | IC50 | = | 41700.0 | nM | 4.38 |