Assay Detail
Binding
CHEMBL4012482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after 2 hrs by HTRF assay
24
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cytochrome P450 11B2, mitochondrial (CHEMBL3621020) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
4-Anilino-pyrimidine, novel aldosterone synthase (CYP11B2) inhibitors bearing pyrimidine structures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.34 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4082403 | — | — | 3 | 9.14 |
| CHEMBL4093575 | — | — | 1 | 7.68 |
| CHEMBL4070323 | — | — | 1 | 6.99 |
| CHEMBL4072871 | — | — | 1 | 6.77 |
| CHEMBL4088766 | — | — | 1 | 6.59 |
| CHEMBL4099824 | — | — | 1 | 6.52 |
| CHEMBL4065476 | — | — | 1 | 6.36 |
| CHEMBL4091167 | — | — | 1 | 6.10 |
| CHEMBL4104118 | — | — | 1 | 6.04 |
| CHEMBL4072943 | — | — | 1 | 5.96 |
| CHEMBL4077051 | — | — | 1 | 5.88 |
| CHEMBL4070230 | — | — | 1 | 5.87 |
| CHEMBL4060559 | — | — | 1 | 5.86 |
| CHEMBL4075207 | — | — | 1 | 5.83 |
| CHEMBL4079006 | — | — | 1 | 5.75 |
| CHEMBL4092081 | — | — | 1 | 5.72 |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | 5.68 |
| CHEMBL4061565 | — | — | 1 | 5.56 |
| CHEMBL4101118 | — | — | 1 | 5.50 |
| CHEMBL4067686 | — | — | 1 | 5.29 |
| CHEMBL4083387 | — | — | 1 | - |
| CHEMBL4064367 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4082403 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL4082403 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4093575 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4070323 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4072871 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4088766 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4099824 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4065476 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4091167 | — | IC50 | = | 798.0 | nM | 6.10 |
| CHEMBL4104118 | — | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL4072943 | — | IC50 | = | 1095.0 | nM | 5.96 |
| CHEMBL4077051 | — | IC50 | = | 1312.0 | nM | 5.88 |
| CHEMBL4070230 | — | IC50 | = | 1339.0 | nM | 5.87 |
| CHEMBL4060559 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4075207 | — | IC50 | = | 1471.0 | nM | 5.83 |
| CHEMBL4079006 | — | IC50 | = | 1757.0 | nM | 5.75 |
| CHEMBL4092081 | — | IC50 | = | 1893.0 | nM | 5.72 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 2074.0 | nM | 5.68 |
| CHEMBL4061565 | — | IC50 | = | 2737.0 | nM | 5.56 |
| CHEMBL4101118 | — | IC50 | = | 3127.0 | nM | 5.50 |
| CHEMBL4067686 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4083387 | — | IC50 | - | — | - | |
| CHEMBL4064367 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4082403 | — | IC50 | > | 100.0 | nM | - |