Assay Detail
Binding
CHEMBL4012501
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at androgen receptor (unknown origin) expressed in African green monkey COS7 cells after 24 hrs by MMTV-promoter driven luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.61 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4090028 | — | — | 1 | 9.72 |
| CHEMBL4060271 | — | — | 1 | 9.70 |
| CHEMBL4092535 | — | — | 1 | 9.54 |
| CHEMBL4068946 | — | — | 1 | 9.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4090028 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4060271 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4092535 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL4068946 | — | IC50 | = | 0.32 | nM | 9.49 |