Assay Detail
Binding
CHEMBL4013232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AChE in human erythrocytes using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured every minute for 10 mins by Ellman's spectrophotometric method
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a "Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.43 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071377 | — | — | 1 | 8.54 |
| CHEMBL4102333 | — | — | 1 | 8.48 |
| CHEMBL4095535 | — | — | 1 | 8.24 |
| CHEMBL4081915 | — | — | 1 | 8.06 |
| CHEMBL4094081 | — | — | 1 | 7.85 |
| CHEMBL4060011 | — | — | 1 | 7.75 |
| CHEMBL4066548 | — | — | 1 | 7.75 |
| CHEMBL4068149 | — | — | 1 | 7.59 |
| CHEMBL4074062 | — | — | 1 | 7.56 |
| CHEMBL4094591 | — | — | 1 | 7.52 |
| CHEMBL4098418 | — | — | 1 | 7.44 |
| CHEMBL4092048 | — | — | 1 | 7.39 |
| CHEMBL4084371 | — | — | 1 | 7.22 |
| CHEMBL4072999 | — | — | 1 | 7.04 |
| CHEMBL4099873 | — | — | 1 | 6.58 |
| CHEMBL4061527 | — | — | 1 | 6.37 |
| CHEMBL4105085 | — | — | 1 | 6.18 |
| CHEMBL4076930 | — | — | 1 | 6.17 |
| CHEMBL4064413 | — | — | 1 | - |
| CHEMBL4092123 | — | — | 1 | - |
| CHEMBL4101303 | — | — | 1 | - |
| CHEMBL4072865 | — | — | 1 | - |
| CHEMBL4093567 | — | — | 1 | - |
| CHEMBL4083445 | — | — | 1 | - |
| CHEMBL4099794 | — | — | 1 | - |
| CHEMBL4081776 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071377 | — | IC50 | = | 2.92 | nM | 8.54 |
| CHEMBL4102333 | — | IC50 | = | 3.27 | nM | 8.48 |
| CHEMBL4095535 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4081915 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4094081 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4060011 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4066548 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4068149 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL4074062 | — | IC50 | = | 27.7 | nM | 7.56 |
| CHEMBL4094591 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4098418 | — | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL4092048 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4084371 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4072999 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4099873 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL4061527 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL4105085 | — | IC50 | = | 653.0 | nM | 6.18 |
| CHEMBL4076930 | — | IC50 | = | 678.0 | nM | 6.17 |
| CHEMBL4064413 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4092123 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4101303 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4072865 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4093567 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4083445 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4099794 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4081776 | — | IC50 | > | 1000.0 | nM | - |