Assay Detail
Binding
CHEMBL4013267
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MMP2 using Mca-PQGL-(3-[2, 4-dinitrophenyl]-L-2, 3-diaminopropionyl)-AR-OH as substrate after 2 to 4 hrs by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.06 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187092 | — | — | 1 | 8.30 |
| CHEMBL4094455 | — | — | 1 | 6.55 |
| CHEMBL4102193 | — | — | 1 | 6.51 |
| CHEMBL4066965 | — | — | 1 | 5.75 |
| CHEMBL4072836 | — | — | 1 | 5.52 |
| CHEMBL3972836 | — | — | 1 | 5.33 |
| CHEMBL3980860 | — | — | 1 | 4.46 |
| CHEMBL3955404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187092 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4094455 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4102193 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4066965 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4072836 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3972836 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3980860 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3955404 | — | IC50 | > | 100000.0 | nM | - |