Assay Detail
Binding
CHEMBL4013289
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human complement factor D catalytic domain (G24 to A253 residues) expressed in expressed in Escherichia coli(Rosetta) using cobra venom factor-factor B complex as substrate preincubated for 1 hr followed by substrate addition measured after 1 hr by ELISA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.39 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065529 | — | — | 1 | 6.68 |
| CHEMBL3908849 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065529 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3908849 | — | IC50 | = | 800.0 | nM | 6.10 |