Assay Detail
Binding
CHEMBL4013311
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Inhibition of complement factor D in human whole blood assessed as decrease in zymosan-induced AP activation mediated soluble MAC complex formation preincubated for 15 mins followed by zymosan addition measured after 40 mins by ELISA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.93 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3683737 | — | — | 1 | 8.05 |
| CHEMBL3683753 | — | — | 1 | 7.96 |
| CHEMBL4098439 | — | — | 1 | 7.66 |
| CHEMBL4081888 | — | — | 1 | 7.46 |
| CHEMBL3678882 | — | — | 1 | 6.82 |
| CHEMBL4094108 | — | — | 1 | 6.60 |
| CHEMBL4070311 | — | — | 1 | 6.23 |
| CHEMBL4065529 | — | — | 1 | 5.90 |
| CHEMBL3683729 | — | — | 1 | 5.73 |
| CHEMBL4075355 | — | — | 1 | - |
| CHEMBL4075037 | — | — | 1 | - |
| CHEMBL4095470 | — | — | 1 | - |
| CHEMBL4061643 | — | — | 1 | - |
| CHEMBL4076955 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3683737 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3683753 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4098439 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4081888 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3678882 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4094108 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4070311 | — | IC50 | = | 587.0 | nM | 6.23 |
| CHEMBL4065529 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL3683729 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL4075355 | — | IC50 | - | — | - | |
| CHEMBL4075037 | — | IC50 | - | — | - | |
| CHEMBL4095470 | — | IC50 | - | — | - | |
| CHEMBL4061643 | — | IC50 | - | — | - | |
| CHEMBL4076955 | — | IC50 | - | — | - |