Assay Detail
Functional
CHEMBL4013329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo inhibition of complement factor D in cynomolgus monkey assessed as decrease in zymosan-induced AP activation by measuring soluble MAC complex deposition in serum administered as single dose via oral gavage measured at 4 to 24 hrs post dose
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Macaca fascicularis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.42 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3683753 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3683753 | — | EC50 | = | 38.0 | nM | 7.42 |