Assay Detail
ADMET
CHEMBL4013333
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Agonist activity at recombinant human 5-HT2A receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT2C Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 70 | 6.63 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4075267 | — | — | 1 | 7.12 |
| CHEMBL4066433 | — | — | 1 | 7.03 |
| CHEMBL4100216 | — | — | 1 | 6.82 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 6.54 |
| CHEMBL4081247 | — | — | 1 | 6.20 |
| CHEMBL4082753 | — | — | 1 | 6.05 |
| CHEMBL4069354 | — | — | 1 | - |
| CHEMBL4064770 | — | — | 1 | - |
| CHEMBL4100812 | — | — | 1 | - |
| CHEMBL4093978 | — | — | 1 | - |
| CHEMBL4070587 | — | — | 1 | - |
| CHEMBL4081550 | — | — | 1 | - |
| CHEMBL4096385 | — | — | 1 | - |
| CHEMBL4078339 | — | — | 1 | - |
| CHEMBL4104126 | — | — | 1 | - |
| CHEMBL4086216 | — | — | 1 | - |
| CHEMBL4100745 | — | — | 1 | - |
| CHEMBL4092473 | — | — | 1 | - |
| CHEMBL4096587 | — | — | 1 | - |
| CHEMBL4095663 | — | — | 1 | - |
| CHEMBL4087951 | — | — | 1 | - |
| CHEMBL4066653 | — | — | 1 | - |
| CHEMBL4065606 | — | — | 1 | - |
| CHEMBL4093250 | — | — | 1 | - |
| CHEMBL4103426 | — | — | 1 | - |
| CHEMBL4085497 | — | — | 1 | - |
| CHEMBL4072337 | — | — | 1 | - |
| CHEMBL4093102 | — | — | 1 | - |
| CHEMBL4082829 | — | — | 1 | - |
| CHEMBL4090637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4075267 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4066433 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4100216 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4081247 | — | EC50 | = | 635.0 | nM | 6.20 |
| CHEMBL4082753 | — | EC50 | = | 884.0 | nM | 6.05 |
| CHEMBL4067417 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4092473 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4096374 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4059884 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4073363 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4083752 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4062011 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4102653 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4084723 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4064770 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4084377 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4088662 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4105011 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4080787 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4070122 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4097390 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4089670 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4078330 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4062613 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4090579 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4061625 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4083432 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4095663 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4090637 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4082829 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4093102 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4072337 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4085497 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4103426 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4093250 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4065606 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4066653 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4087951 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4100745 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4096587 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4069354 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4100812 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4093978 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4070587 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4081550 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4096385 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4078339 | — | EC50 | >= | 1800.0 | nM | - |
| CHEMBL4104126 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4086216 | — | EC50 | > | 5000.0 | nM | - |