Compound Detail
CHEMBL4066433
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Basic Information
| ChEMBL ID | CHEMBL4066433 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XSRAXIUIAKZFGP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
288.4
MW (Da)
3.64
ALogP
4
HBA
0
HBD
35.6
PSA (Ų)
0.56
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C CHEMBL225 | EC50 | 7.24 | 7.24 | 58.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | EC50 | 7.03 | 7.03 | 93.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | EC50 | = | 58.0 | nM | 7.24 | Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells... | 28635286 |
| 5-hydroxytryptamine receptor 2A | EC50 | = | 93.0 | nM | 7.03 | Agonist activity at recombinant human 5-HT2A receptor expressed in HEK293E cells... | 28635286 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28635286 | 10.1021/acs.jmedchem.7b00385 | 5-hydroxytryptamine receptor 2C | 2 |
| 28635286 | 10.1021/acs.jmedchem.7b00385 | 5-hydroxytryptamine receptor 2A | 2 |
| 28635286 | 10.1021/acs.jmedchem.7b00385 | 5-hydroxytryptamine receptor 2B | 1 |
| 28635286 | 10.1021/acs.jmedchem.7b00385 | Liver | 1 |
Data from ChEMBL 36 via Core Engine