Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4013737

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation counting
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Estrogen receptor (CHEMBL206)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells.
Min J, Guillen VS, Sharma A, Zhao Y, Ziegler Y, Gong P, Mayne CG, Srinivasan S, Kim SH, Carlson KE, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA.
J Med Chem (2017) 60 : 6321 -6336
PubMed 28657320 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 9.20 9.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4065838 1 9.89
CHEMBL4060067 1 9.74
CHEMBL4079530 1 9.57
CHEMBL4083780 1 9.49
CHEMBL4070669 1 9.46
CHEMBL4102857 1 9.44
CHEMBL4099302 1 9.43
CHEMBL4079644 1 9.43
CHEMBL4062045 1 9.43
CHEMBL4097562 1 9.42
CHEMBL4083658 1 9.40
CHEMBL4078577 1 9.37
CHEMBL4060817 1 9.37
CHEMBL4089824 1 9.35
CHEMBL4073395 1 9.24
CHEMBL4100247 1 9.19
CHEMBL4098470 1 9.15
CHEMBL4081283 1 9.15
CHEMBL4098232 1 9.15
CHEMBL4081969 1 9.13
CHEMBL1091535 1 9.00
CHEMBL4071436 1 8.96
CHEMBL4091563 1 8.88
CHEMBL4068722 1 8.85
CHEMBL4101656 1 8.77
CHEMBL4099166 1 8.74
CHEMBL4082698 1 8.48
CHEMBL4072205 1 8.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4065838 Ki = 0.13 nM 9.89
CHEMBL4060067 Ki = 0.18 nM 9.74
CHEMBL4079530 Ki = 0.27 nM 9.57
CHEMBL4083780 Ki = 0.32 nM 9.49
CHEMBL4070669 Ki = 0.35 nM 9.46
CHEMBL4102857 Ki = 0.36 nM 9.44
CHEMBL4099302 Ki = 0.37 nM 9.43
CHEMBL4079644 Ki = 0.37 nM 9.43
CHEMBL4062045 Ki = 0.37 nM 9.43
CHEMBL4097562 Ki = 0.38 nM 9.42
CHEMBL4083658 Ki = 0.4 nM 9.40
CHEMBL4078577 Ki = 0.43 nM 9.37
CHEMBL4060817 Ki = 0.43 nM 9.37
CHEMBL4089824 Ki = 0.45 nM 9.35
CHEMBL4073395 Ki = 0.57 nM 9.24
CHEMBL4100247 Ki = 0.65 nM 9.19
CHEMBL4098470 Ki = 0.71 nM 9.15
CHEMBL4081283 Ki = 0.71 nM 9.15
CHEMBL4098232 Ki = 0.71 nM 9.15
CHEMBL4081969 Ki = 0.74 nM 9.13
CHEMBL1091535 Ki = 1.0 nM 9.00
CHEMBL4071436 Ki = 1.1 nM 8.96
CHEMBL4091563 Ki = 1.33 nM 8.88
CHEMBL4068722 Ki = 1.4 nM 8.85
CHEMBL4101656 Ki = 1.7 nM 8.77
CHEMBL4099166 Ki = 1.8 nM 8.74
CHEMBL4082698 Ki = 3.3 nM 8.48
CHEMBL4072205 Ki = 7.1 nM 8.15