Assay Detail
Functional
CHEMBL4013830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SNU16 cells over-expressing FGFR2 after 72 hrs by Presto-Blue assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 8.43 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4102642 | — | — | 1 | 9.52 |
| CHEMBL4099992 | — | — | 1 | 9.30 |
| CHEMBL4064081 | — | — | 1 | 9.05 |
| CHEMBL4064756 | — | — | 1 | 8.92 |
| CHEMBL4062003 | — | — | 1 | 8.92 |
| CHEMBL4061286 | — | — | 1 | 8.85 |
| CHEMBL4099578 | — | — | 1 | 8.82 |
| CHEMBL4083740 | — | — | 1 | 8.74 |
| CHEMBL4086567 | — | — | 1 | 8.68 |
| CHEMBL4081984 | — | — | 1 | 8.66 |
| CHEMBL4068509 | PRN-1371 | 1.0 | 1 | 8.59 |
| CHEMBL4095844 | — | — | 1 | 8.47 |
| CHEMBL4089842 | — | — | 1 | 8.47 |
| CHEMBL4061766 | — | — | 1 | 8.46 |
| CHEMBL4066763 | — | — | 1 | 8.46 |
| CHEMBL4092456 | — | — | 1 | 8.42 |
| CHEMBL4084708 | — | — | 1 | 8.39 |
| CHEMBL4088057 | — | — | 1 | 8.33 |
| CHEMBL4095783 | — | — | 1 | 8.28 |
| CHEMBL4083151 | — | — | 1 | 8.17 |
| CHEMBL4073347 | — | — | 1 | 7.96 |
| CHEMBL4091839 | — | — | 1 | 7.77 |
| CHEMBL4065128 | — | — | 1 | 7.58 |
| CHEMBL4102058 | — | — | 1 | 7.57 |
| CHEMBL4084079 | — | — | 1 | 7.47 |
| CHEMBL4100201 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4102642 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4099992 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4064081 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4064756 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4062003 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4061286 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4099578 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4083740 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4086567 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4081984 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4068509 | PRN-1371 | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4095844 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4089842 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4061766 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4066763 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4092456 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4084708 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4088057 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4095783 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4083151 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4073347 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4091839 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4065128 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4102058 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4084079 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4100201 | — | IC50 | = | 51.0 | nM | 7.29 |