Assay Detail
Binding
CHEMBL4013920
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Inhibition of recombinant MPO (unknown origin) assessed as reduction in LDL oxidation in presence of H2O2 and HCl after 5 mins by ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.15 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL581893 | — | — | 1 | 7.05 |
| CHEMBL4064328 | — | — | 1 | 6.92 |
| CHEMBL686 | MEFENAMIC ACID | 4.0 | 1 | 5.66 |
| CHEMBL276832 | HYDRALAZINE | 4.0 | 1 | 5.63 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.51 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | - |
| CHEMBL251689 | — | — | 1 | - |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | - |
| CHEMBL4098162 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL581893 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4064328 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL686 | MEFENAMIC ACID | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL276832 | HYDRALAZINE | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL50 | QUERCETIN | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL150 | KAEMPFEROL | IC50 | - | — | - | |
| CHEMBL251689 | — | IC50 | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | > | 5000.0 | nM | - |
| CHEMBL4098162 | — | IC50 | - | — | - |