Assay Detail
Functional
CHEMBL4014022
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by WST8 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Conformation-Based Design and Synthesis of Apratoxin A Mimetics Modified at the α,β-Unsaturated Thiazoline Moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.48 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4064999 | — | — | 1 | 8.96 |
| CHEMBL501696 | APRATOXIN A | — | 1 | 8.55 |
| CHEMBL4089316 | — | — | 1 | 7.16 |
| CHEMBL4097366 | — | — | 1 | 6.92 |
| CHEMBL4081442 | — | — | 1 | 6.89 |
| CHEMBL4085320 | — | — | 1 | 6.66 |
| CHEMBL4066467 | — | — | 1 | 6.47 |
| CHEMBL4069821 | — | — | 1 | 6.44 |
| CHEMBL4061150 | — | — | 1 | 6.31 |
| CHEMBL4091724 | — | — | 1 | 6.15 |
| CHEMBL4063715 | — | — | 1 | 6.09 |
| CHEMBL4070851 | — | — | 1 | 6.07 |
| CHEMBL4097018 | — | — | 1 | 5.80 |
| CHEMBL4094012 | — | — | 1 | 5.58 |
| CHEMBL4075065 | — | — | 1 | 5.51 |
| CHEMBL4101741 | — | — | 1 | 5.47 |
| CHEMBL4099463 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4064999 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL501696 | APRATOXIN A | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4089316 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4097366 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4081442 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4085320 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4066467 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4069821 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4061150 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4091724 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4063715 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4070851 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4097018 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4094012 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4075065 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4101741 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4099463 | — | IC50 | = | 7500.0 | nM | 5.12 |