Assay Detail
Binding
CHEMBL4014111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation counting
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK1 (CHEMBL4224) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.10 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4083249 | — | — | 1 | 8.70 |
| CHEMBL4094600 | — | — | 1 | 8.22 |
| CHEMBL4096379 | — | — | 1 | 8.15 |
| CHEMBL408982 | — | — | 1 | 7.77 |
| CHEMBL4072795 | — | — | 1 | 7.75 |
| CHEMBL4067143 | — | — | 1 | 7.62 |
| CHEMBL4060440 | — | — | 1 | 7.54 |
| CHEMBL4093503 | — | — | 1 | 7.52 |
| CHEMBL4104765 | — | — | 1 | 7.47 |
| CHEMBL4088668 | — | — | 1 | 7.44 |
| CHEMBL4069124 | — | — | 1 | 7.19 |
| CHEMBL4104122 | — | — | 1 | 7.18 |
| CHEMBL4079878 | — | — | 1 | 6.86 |
| CHEMBL4064426 | — | — | 1 | 6.81 |
| CHEMBL4086890 | — | — | 1 | 6.76 |
| CHEMBL4100703 | — | — | 1 | 6.73 |
| CHEMBL4081470 | — | — | 1 | 6.72 |
| CHEMBL4063617 | — | — | 1 | 6.55 |
| CHEMBL4092984 | — | — | 1 | 6.37 |
| CHEMBL4072220 | — | — | 1 | 6.36 |
| CHEMBL4082710 | — | — | 1 | 6.28 |
| CHEMBL4104093 | — | — | 1 | 6.00 |
| CHEMBL4078073 | — | — | 1 | 5.30 |
| CHEMBL4059498 | — | — | 1 | - |
| CHEMBL4102344 | — | — | 1 | - |
| CHEMBL4074986 | — | — | 1 | - |
| CHEMBL4101671 | — | — | 1 | - |
| CHEMBL4085242 | — | — | 1 | - |
| CHEMBL4086182 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4083249 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4094600 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4096379 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL408982 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4072795 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4067143 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4060440 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4093503 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4104765 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4088668 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4069124 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4104122 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4079878 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4064426 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL4086890 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4100703 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4081470 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL4063617 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4092984 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4072220 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL4082710 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL4104093 | — | IC50 | = | 993.0 | nM | 6.00 |
| CHEMBL4078073 | — | IC50 | = | 4985.0 | nM | 5.30 |
| CHEMBL4059498 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4102344 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4074986 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4101671 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4085242 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4086182 | — | IC50 | > | 10000.0 | nM | - |