Assay Detail
Binding
CHEMBL4014420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged PTP1B (1 to 321 residues) (unknown origin) using p-NPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.79 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4095230 | — | — | 1 | 6.38 |
| CHEMBL4087528 | — | — | 1 | 6.35 |
| CHEMBL4067813 | — | — | 1 | 5.80 |
| CHEMBL4086544 | — | — | 1 | 5.75 |
| CHEMBL4102979 | — | — | 1 | 5.70 |
| CHEMBL1232829 | — | — | 1 | 5.70 |
| CHEMBL4078699 | — | — | 1 | 5.57 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4095230 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4087528 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4067813 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4086544 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4102979 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1232829 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4078699 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 8900.0 | nM | 5.05 |