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Assay Detail

CHEMBL4014441

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type BV-2
Confidence 1 — Organism
Curated By Autocuration

Target

BV-2 (CHEMBL614781)
Type CELL-LINE
Organism Mus musculus

Publication

Anti-inflammatory and Antiosteoporosis Flavonoids from the Rhizomes of Helminthostachys zeylanica.
Huang YL, Shen CC, Shen YC, Chiou WF, Chen CC.
J Nat Prod (2017) 80 : 246 -253
PubMed 28169537 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.00 5.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4070007 1 5.21
CHEMBL4060322 1 5.19
CHEMBL4096267 1 5.17
CHEMBL4088204 1 5.16
CHEMBL550505 UGONIN O 1 5.11
CHEMBL4088548 1 5.09
CHEMBL550368 UGONIN L 1 5.00
CHEMBL560314 UGONIN M 1 5.00
CHEMBL399491 PYRROLIDINE DITHIOCARBAMATE 1 4.97
CHEMBL4066932 1 4.75
CHEMBL2308661 1 4.71
CHEMBL4090988 1 4.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4070007 IC50 = 6200.0 nM 5.21
CHEMBL4060322 IC50 = 6500.0 nM 5.19
CHEMBL4096267 IC50 = 6700.0 nM 5.17
CHEMBL4088204 IC50 = 7000.0 nM 5.16
CHEMBL550505 UGONIN O IC50 = 7700.0 nM 5.11
CHEMBL4088548 IC50 = 8100.0 nM 5.09
CHEMBL550368 UGONIN L IC50 = 10100.0 nM 5.00
CHEMBL560314 UGONIN M IC50 = 10100.0 nM 5.00
CHEMBL399491 PYRROLIDINE DITHIOCARBAMATE IC50 = 10800.0 nM 4.97
CHEMBL4066932 IC50 = 18000.0 nM 4.75
CHEMBL2308661 IC50 = 19700.0 nM 4.71
CHEMBL4090988 IC50 = 24100.0 nM 4.62