Assay Detail
Functional
CHEMBL4014442
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Antiosteoporotic activity in mouse RAW264.7 cells assessed as inhibition of RANKL-induced osteoclast differentiation after 4 to 5 days by TRAP assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-inflammatory and Antiosteoporosis Flavonoids from the Rhizomes of Helminthostachys zeylanica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.43 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088548 | — | — | 1 | 5.75 |
| CHEMBL560314 | UGONIN M | — | 1 | 5.60 |
| CHEMBL4096267 | — | — | 1 | 5.50 |
| CHEMBL550505 | UGONIN O | — | 1 | 5.48 |
| CHEMBL4088204 | — | — | 1 | 5.46 |
| CHEMBL4066932 | — | — | 1 | 5.35 |
| CHEMBL2308661 | — | — | 1 | 5.34 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 4.94 |
| CHEMBL4090988 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088548 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL560314 | UGONIN M | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4096267 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL550505 | UGONIN O | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4088204 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4066932 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2308661 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL44 | GENISTEIN | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4090988 | — | IC50 | > | 10000.0 | nM | - |