Assay Detail
Binding
CHEMBL4014504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/Puerto Rico/8/34(H1N1)) neuraminidase activity infected in MDCK cells assessed as reduction in progeny production using 2-(4-Methylumbelliferyl)-a-D-N-acetylneuraminic acid sodium salt as substrate pretreated for 1 hr with virus followed by 1 hr infection in MDCK cells measured after 48 hrs by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Oligothiophene compounds inhibit the membrane fusion between H5N1 avian influenza virus and the endosome of host cell.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.52 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4092514 | — | — | 1 | 6.12 |
| CHEMBL4065971 | — | — | 1 | 5.95 |
| CHEMBL4097905 | — | — | 1 | 5.91 |
| CHEMBL4086247 | — | — | 1 | 5.48 |
| CHEMBL2088468 | — | — | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4092514 | — | IC50 | = | 768.0 | nM | 6.12 |
| CHEMBL4065971 | — | IC50 | = | 1119.0 | nM | 5.95 |
| CHEMBL4097905 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4086247 | — | IC50 | = | 3292.0 | nM | 5.48 |
| CHEMBL2088468 | — | IC50 | = | 72000.0 | nM | 4.14 |