Assay Detail
Binding
CHEMBL4014528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BTK
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.27 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4105195 | — | — | 1 | 5.30 |
| CHEMBL4087337 | — | — | 1 | 5.30 |
| CHEMBL490355 | SULFURETIN | — | 1 | 5.22 |
| CHEMBL3334979 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4105195 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4087337 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL490355 | SULFURETIN | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL3334979 | — | IC50 | - | — | - |