Assay Detail
Functional
CHEMBL4014622
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild-type HIV1 3B infected in human MT4 cells assessed as protection against virus-induced cytopathic effect measured at 5 days post infection by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.21 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089736 | — | — | 1 | 8.25 |
| CHEMBL4092124 | — | — | 1 | 8.11 |
| CHEMBL4090408 | — | — | 1 | 7.47 |
| CHEMBL4082481 | — | — | 1 | 7.47 |
| CHEMBL4081872 | — | — | 1 | 7.34 |
| CHEMBL4068534 | — | — | 1 | 7.08 |
| CHEMBL4076240 | — | — | 1 | 6.92 |
| CHEMBL4100493 | — | — | 1 | 6.77 |
| CHEMBL4061618 | — | — | 1 | 6.28 |
| CHEMBL4072969 | — | — | 1 | 6.28 |
| CHEMBL4099874 | — | — | 1 | 6.06 |
| CHEMBL4078076 | — | — | 1 | 5.57 |
| CHEMBL4090565 | — | — | 1 | 5.24 |
| CHEMBL4074746 | — | — | 1 | 5.18 |
| CHEMBL4077635 | — | — | 1 | 5.11 |
| CHEMBL4098295 | — | — | 1 | 5.03 |
| CHEMBL4088133 | — | — | 1 | 4.83 |
| CHEMBL4094385 | — | — | 1 | 4.72 |
| CHEMBL4101429 | — | — | 1 | 4.31 |
| CHEMBL4069548 | — | — | 1 | - |
| CHEMBL4086833 | — | — | 1 | - |
| CHEMBL4095860 | — | — | 1 | - |
| CHEMBL4085963 | — | — | 1 | - |
| CHEMBL4080253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089736 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4092124 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4090408 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4082481 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4081872 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4068534 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4076240 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4100493 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4061618 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4072969 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4099874 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4078076 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4090565 | — | EC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL4074746 | — | EC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL4077635 | — | EC50 | = | 7730.0 | nM | 5.11 |
| CHEMBL4098295 | — | EC50 | = | 9380.0 | nM | 5.03 |
| CHEMBL4088133 | — | EC50 | = | 14930.0 | nM | 4.83 |
| CHEMBL4094385 | — | EC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4101429 | — | EC50 | = | 48810.0 | nM | 4.31 |
| CHEMBL4069548 | — | EC50 | > | 99530.0 | nM | - |
| CHEMBL4086833 | — | EC50 | > | 56470.0 | nM | - |
| CHEMBL4095860 | — | EC50 | > | 2890.0 | nM | - |
| CHEMBL4085963 | — | EC50 | > | 45820.0 | nM | - |
| CHEMBL4080253 | — | EC50 | > | 42300.0 | nM | - |