Assay Detail
Functional
CHEMBL4014623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 RES056 harboring K103N/Y181C double mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect measured at 5 days post infection by MTT assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 7.27 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.47 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.28 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.15 |
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | 7.50 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.58 |
| CHEMBL4089736 | — | — | 1 | 4.63 |
| CHEMBL4094385 | — | — | 1 | - |
| CHEMBL4088133 | — | — | 1 | - |
| CHEMBL4085963 | — | — | 1 | - |
| CHEMBL4100493 | — | — | 1 | - |
| CHEMBL4082481 | — | — | 1 | - |
| CHEMBL4080253 | — | — | 1 | - |
| CHEMBL4098295 | — | — | 1 | - |
| CHEMBL4069548 | — | — | 1 | - |
| CHEMBL4090565 | — | — | 1 | - |
| CHEMBL4095860 | — | — | 1 | - |
| CHEMBL4068534 | — | — | 1 | - |
| CHEMBL4078076 | — | — | 1 | - |
| CHEMBL4090408 | — | — | 1 | - |
| CHEMBL4101429 | — | — | 1 | - |
| CHEMBL4074746 | — | — | 1 | - |
| CHEMBL4072969 | — | — | 1 | - |
| CHEMBL4076240 | — | — | 1 | - |
| CHEMBL4086833 | — | — | 1 | - |
| CHEMBL4077635 | — | — | 1 | - |
| CHEMBL4061618 | — | — | 1 | - |
| CHEMBL4092124 | — | — | 1 | - |
| CHEMBL4099874 | — | — | 1 | - |
| CHEMBL4081872 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL929 | DELAVIRDINE MESYLATE | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4089736 | — | EC50 | = | 23290.0 | nM | 4.63 |
| CHEMBL4094385 | — | EC50 | > | 203500.0 | nM | - |
| CHEMBL4088133 | — | EC50 | > | 299100.0 | nM | - |
| CHEMBL4085963 | — | EC50 | - | — | - | |
| CHEMBL4100493 | — | EC50 | > | 298000.0 | nM | - |
| CHEMBL4082481 | — | EC50 | > | 264700.0 | nM | - |
| CHEMBL4080253 | — | EC50 | - | — | - | |
| CHEMBL4098295 | — | EC50 | > | 27880.0 | nM | - |
| CHEMBL4069548 | — | EC50 | - | — | - | |
| CHEMBL4090565 | — | EC50 | > | 26250.0 | nM | - |
| CHEMBL4095860 | — | EC50 | > | 2890.0 | nM | - |
| CHEMBL4068534 | — | EC50 | > | 3330.0 | nM | - |
| CHEMBL4078076 | — | EC50 | > | 119300.0 | nM | - |
| CHEMBL4090408 | — | EC50 | > | 309100.0 | nM | - |
| CHEMBL4101429 | — | EC50 | > | 74820.0 | nM | - |
| CHEMBL4074746 | — | EC50 | > | 35840.0 | nM | - |
| CHEMBL4072969 | — | EC50 | > | 271700.0 | nM | - |
| CHEMBL4076240 | — | EC50 | > | 284800.0 | nM | - |
| CHEMBL4086833 | — | EC50 | - | — | - | |
| CHEMBL4077635 | — | EC50 | > | 20640.0 | nM | - |
| CHEMBL4061618 | — | EC50 | > | 44130.0 | nM | - |
| CHEMBL4092124 | — | EC50 | > | 2490.0 | nM | - |
| CHEMBL4099874 | — | EC50 | > | 322300.0 | nM | - |
| CHEMBL4081872 | — | EC50 | > | 11650.0 | nM | - |