Assay Detail
Functional
CHEMBL4014630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 harboring Y188L mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect measured at 5 days post infection by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.26 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.96 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.66 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.47 |
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | 6.16 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.02 |
| CHEMBL4089736 | — | — | 1 | 4.28 |
| CHEMBL4100493 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL929 | DELAVIRDINE MESYLATE | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL4089736 | — | EC50 | = | 51950.0 | nM | 4.28 |
| CHEMBL4100493 | — | EC50 | > | 298000.0 | nM | - |