Assay Detail
Binding
CHEMBL4014736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP1B1 expressed in yeast microsomal membranes using 7-ethoxyresorufin as substrate by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazoline derivatives as selective CYP1B1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.47 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4074105 | — | — | 1 | 8.70 |
| CHEMBL2058057 | — | — | 1 | 8.52 |
| CHEMBL4100866 | — | — | 1 | 8.40 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 7.30 |
| CHEMBL3289112 | — | — | 1 | 7.27 |
| CHEMBL4084413 | — | — | 1 | 6.57 |
| CHEMBL4081914 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4074105 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2058057 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4100866 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3289112 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4084413 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL4081914 | — | IC50 | = | 3100.0 | nM | 5.51 |