Assay Detail
ADMET
CHEMBL4014737
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Inhibition of human CYP1A2 expressed in yeast microsomal membranes using 7-ethoxyresorufin/3-cyano-7-ethoxycoumarin/7-ethoxy-methyloxy-3-cyanocoumarin as substrate by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Subcellular | Microsomal Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazoline derivatives as selective CYP1B1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.56 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 7.52 |
| CHEMBL4084413 | — | — | 1 | 5.30 |
| CHEMBL4081914 | — | — | 1 | 5.00 |
| CHEMBL4074105 | — | — | 1 | 5.00 |
| CHEMBL4100866 | — | — | 1 | 5.00 |
| CHEMBL2058057 | — | — | 1 | - |
| CHEMBL3289112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4084413 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4081914 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4074105 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4100866 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2058057 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3289112 | — | IC50 | > | 10000.0 | nM | - |