Assay Detail
ADMET
CHEMBL4014748
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Inhibition of recombinant human liver CYP1A1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substrate addition measured for 60 mins by EROD assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazoline derivatives as selective CYP1B1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.72 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100866 | — | — | 1 | 5.96 |
| CHEMBL4074105 | — | — | 1 | 5.85 |
| CHEMBL4084413 | — | — | 1 | 5.34 |
| CHEMBL2058057 | — | — | 1 | - |
| CHEMBL3289112 | — | — | 1 | - |
| CHEMBL4081914 | — | — | 1 | - |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100866 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4074105 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4084413 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL2058057 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3289112 | — | IC50 | > | 4500.0 | nM | - |
| CHEMBL4081914 | — | IC50 | > | 1275.0 | nM | - |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | > | 10000.0 | nM | - |