Assay Detail
Functional
CHEMBL4015109
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 4.88 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.58 |
| CHEMBL4101478 | — | — | 1 | 5.42 |
| CHEMBL4103919 | — | — | 1 | 5.40 |
| CHEMBL4067187 | — | — | 1 | 5.17 |
| CHEMBL4079026 | — | — | 1 | 4.85 |
| CHEMBL4093702 | — | — | 1 | 4.77 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 4.70 |
| CHEMBL4094596 | — | — | 1 | 4.51 |
| CHEMBL4074796 | — | — | 1 | 4.43 |
| CHEMBL4067136 | — | — | 1 | 4.36 |
| CHEMBL1276861 | — | — | 1 | 4.30 |
| CHEMBL4099805 | — | — | 1 | 4.01 |
| CHEMBL3621824 | — | — | 1 | - |
| CHEMBL3621826 | — | — | 1 | - |
| CHEMBL3622214 | — | — | 1 | - |
| CHEMBL3622215 | — | — | 1 | - |
| CHEMBL4069285 | — | — | 1 | - |
| CHEMBL4080713 | — | — | 1 | - |
| CHEMBL4098759 | — | — | 1 | - |
| CHEMBL4072770 | — | — | 1 | - |
| CHEMBL4101832 | — | — | 1 | - |
| CHEMBL4071249 | — | — | 1 | - |
| CHEMBL4084303 | — | — | 1 | - |
| CHEMBL4061374 | — | — | 1 | - |
| CHEMBL4083231 | — | — | 1 | - |
| CHEMBL3621822 | — | — | 1 | - |
| CHEMBL4093030 | — | — | 1 | - |
| CHEMBL4065363 | — | — | 1 | - |
| CHEMBL4100746 | — | — | 1 | - |
| CHEMBL4073975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4101478 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4103919 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4067187 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4079026 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4093702 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4094596 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4074796 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4067136 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1276861 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4099805 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL3621818 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4063413 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621819 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621817 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4086886 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621821 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621815 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621767 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3621763 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4068153 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4097038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4060294 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4073002 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4089337 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4088445 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4104762 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4092057 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4066182 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4093758 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4101832 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4073975 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4100746 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4065363 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4093030 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621822 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4083231 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4061374 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4084303 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4071249 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3621837 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4072770 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4098759 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4080713 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4069285 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3622215 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3622214 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621826 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621824 | — | IC50 | > | 100000.0 | nM | - |