Assay Detail
Functional
CHEMBL4015219
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
66
Total Activities
63
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 63 | 6.14 | 7.38 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088884 | — | — | 2 | 7.38 |
| CHEMBL4101728 | — | — | 2 | 7.10 |
| CHEMBL4062512 | — | — | 1 | 6.95 |
| CHEMBL4078546 | — | — | 1 | 6.73 |
| CHEMBL446452 | ARUNDINE | 3.0 | 2 | 6.60 |
| CHEMBL4075099 | — | — | 1 | 6.58 |
| CHEMBL4101219 | — | — | 1 | 6.48 |
| CHEMBL246298 | — | — | 1 | 6.44 |
| CHEMBL4096571 | — | — | 1 | 6.42 |
| CHEMBL4087824 | — | — | 1 | 6.26 |
| CHEMBL4082668 | — | — | 1 | 6.20 |
| CHEMBL221137 | EMBELIN | — | 1 | 6.10 |
| CHEMBL4077871 | — | — | 1 | 6.01 |
| CHEMBL4066454 | — | — | 1 | 5.94 |
| CHEMBL4095532 | — | — | 1 | 5.72 |
| CHEMBL246504 | — | — | 1 | 5.46 |
| CHEMBL4096406 | — | — | 1 | 5.30 |
| CHEMBL107498 | DECANOIC ACID | — | 1 | 5.13 |
| CHEMBL4103279 | — | — | 1 | 5.00 |
| CHEMBL4104992 | — | — | 1 | 4.97 |
| CHEMBL2376559 | — | — | 1 | - |
| CHEMBL4100585 | — | — | 1 | - |
| CHEMBL4073783 | — | — | 1 | - |
| CHEMBL522998 | — | — | 1 | - |
| CHEMBL1995195 | — | — | 1 | - |
| CHEMBL4066500 | — | — | 1 | - |
| CHEMBL4087204 | — | — | 1 | - |
| CHEMBL1939127 | — | — | 1 | - |
| CHEMBL4085348 | — | — | 1 | - |
| CHEMBL190134 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088884 | — | EC50 | = | 41.3 | nM | 7.38 |
| CHEMBL4101728 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4062512 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4078546 | — | EC50 | = | 187.0 | nM | 6.73 |
| CHEMBL446452 | ARUNDINE | EC50 | = | 252.0 | nM | 6.60 |
| CHEMBL4075099 | — | EC50 | = | 264.0 | nM | 6.58 |
| CHEMBL4101219 | — | EC50 | = | 328.0 | nM | 6.48 |
| CHEMBL246298 | — | EC50 | = | 365.0 | nM | 6.44 |
| CHEMBL4096571 | — | EC50 | = | 377.0 | nM | 6.42 |
| CHEMBL4087824 | — | EC50 | = | 553.0 | nM | 6.26 |
| CHEMBL4082668 | — | EC50 | = | 625.0 | nM | 6.20 |
| CHEMBL221137 | EMBELIN | EC50 | = | 795.0 | nM | 6.10 |
| CHEMBL4077871 | — | EC50 | = | 987.0 | nM | 6.01 |
| CHEMBL4066454 | — | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4095532 | — | EC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL246504 | — | EC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL4096406 | — | EC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL107498 | DECANOIC ACID | EC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL4103279 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4104992 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4087988 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4059692 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4095700 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4068351 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4103460 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4079202 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4100658 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL446452 | ARUNDINE | Inhibition | - | % | - | |
| CHEMBL574467 | — | EC50 | >= | 10000.0 | nM | - |
| CHEMBL4093996 | — | EC50 | >= | 10000.0 | nM | - |
| CHEMBL4101728 | — | Inhibition | - | % | - | |
| CHEMBL4104139 | — | EC50 | >= | 10000.0 | nM | - |
| CHEMBL578425 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4100764 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4082773 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1914909 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4074055 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4093108 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL190134 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4085348 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2376559 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4100585 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4073783 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL522998 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1995195 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1939127 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4066500 | — | EC50 | >= | 10000.0 | nM | - |
| CHEMBL2376692 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4087204 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL574338 | — | EC50 | > | 10000.0 | nM | - |