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Assay Detail

CHEMBL4015253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at human PK-tagged GPR84 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase complementation assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

G-protein coupled receptor 84 (CHEMBL3714079)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84.
Pillaiyar T, Köse M, Sylvester K, Weighardt H, Thimm D, Borges G, Förster I, von Kügelgen I, Müller CE.
J Med Chem (2017) 60 : 3636 -3655
PubMed 28406627 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 6.38 6.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL221137 EMBELIN 1 6.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL221137 EMBELIN EC50 = 421.0 nM 6.38