Assay Detail
Binding
CHEMBL4015708
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of ABCG2 (unknown origin) ATPase activity expressed in baculovirus infected high five cell membranes by ascorbic acid/ammonia molybdate reaction-based colorimetric analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Broad substrate specificity ATP-binding cassette transporter ABCG2 (CHEMBL5393) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Anilino-2-pyridylquinazolines and -pyrimidines as Highly Potent and Nontoxic Inhibitors of Breast Cancer Resistance Protein (ABCG2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 7.11 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081708 | — | — | 1 | 8.40 |
| CHEMBL4082228 | — | — | 1 | 8.40 |
| CHEMBL4083491 | — | — | 1 | 8.15 |
| CHEMBL4075328 | — | — | 1 | 8.05 |
| CHEMBL4082355 | — | — | 1 | 8.00 |
| CHEMBL2158558 | — | — | 1 | 7.82 |
| CHEMBL4059784 | — | — | 1 | 7.80 |
| CHEMBL4069582 | — | — | 1 | 7.70 |
| CHEMBL4098723 | — | — | 1 | 7.68 |
| CHEMBL4083108 | — | — | 1 | 7.66 |
| CHEMBL4090505 | — | — | 1 | 7.38 |
| CHEMBL4071162 | — | — | 1 | 7.30 |
| CHEMBL4097911 | — | — | 1 | 7.24 |
| CHEMBL1499954 | — | — | 1 | 7.16 |
| CHEMBL4082677 | — | — | 1 | 7.10 |
| CHEMBL4077632 | — | — | 1 | 7.09 |
| CHEMBL4062126 | — | — | 1 | 7.07 |
| CHEMBL4085567 | — | — | 1 | 6.88 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 6.56 |
| CHEMBL4089579 | — | — | 1 | 6.46 |
| CHEMBL4071711 | — | — | 1 | 6.17 |
| CHEMBL4068441 | — | — | 1 | 5.82 |
| CHEMBL4099533 | — | — | 1 | 5.81 |
| CHEMBL4088963 | — | — | 1 | 5.75 |
| CHEMBL4096657 | — | — | 1 | 5.68 |
| CHEMBL4069428 | — | — | 1 | 5.61 |
| CHEMBL4060750 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081708 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4082228 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4083491 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4075328 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4082355 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2158558 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4059784 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4069582 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4098723 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4083108 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4090505 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4071162 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4097911 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1499954 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4082677 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4077632 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4062126 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4085567 | — | EC50 | = | 131.0 | nM | 6.88 |
| CHEMBL50 | QUERCETIN | EC50 | = | 278.0 | nM | 6.56 |
| CHEMBL4089579 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4071711 | — | EC50 | = | 676.0 | nM | 6.17 |
| CHEMBL4068441 | — | EC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4099533 | — | EC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4088963 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4096657 | — | EC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4069428 | — | EC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL4060750 | — | EC50 | - | — | - |