Assay Detail

CHEMBL4015839

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Binding

Inhibition of SMAC-derived peptide abuRPFK (5 and 6FAM)-amide interaction with cIAP1 BIR3 domain (unknown origin) by fluorescence polarization assay

ChEMBL ↗

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Target

Baculoviral IAP repeat-containing protein 2 (CHEMBL5462) ↗

Open DB target context

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Baculoviral IAP repeat-containing protein 2 (CHEMBL5462) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Baculoviral IAP repeat-containing protein 2

CHEMBL5462

Anchored from Assay target.

Protein identity Baculoviral IAP repeat-containing protein 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Baculoviral IAP repeat-containing protein 2 (CHEMBL5462) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).

Tamanini E, Buck IM, Chessari G, Chiarparin E, Day JEH, Frederickson M, Griffiths-Jones CM, Hearn K, Heightman TD, Iqbal A, Johnson CN, Lewis EJ, Martins V, Peakman T, Reader M, Rich SJ, Ward GA, Williams PA, Wilsher NE.
J Med Chem (2017) 60 : 4611 -4625
PubMed 28492317 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.67	9.49

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL234346	—	—	1	9.49
CHEMBL3700016	—	—	1	7.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL234346	—	IC50	=	0.32	nM	9.49
CHEMBL3700016	—	IC50	=	14.0	nM	7.85