Assay Detail
Functional
CHEMBL4016327
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Antiproliferative activity against human HT1080 cells transfected with CYP1A1 after 72 hrs by SRB assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.12 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802510 | — | — | 1 | 8.77 |
| CHEMBL1802509 | — | — | 1 | 8.64 |
| CHEMBL4078072 | — | — | 1 | 7.89 |
| CHEMBL4096550 | — | — | 1 | 7.80 |
| CHEMBL4104764 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802510 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1802509 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4078072 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4096550 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4104764 | — | IC50 | = | 31.0 | nM | 7.51 |